78 List of $EST Options and Their Relevance to Various Methods

Introduction to NONMEM 7.6.0

Author

Robert J. Bauer

Published

June 1, 2025

The following table lists $EST options and marks which estimation methods utilize each option.

Option	Classical	`ITS`	DIRECT	`IMP`	`IMPMAP`	`SAEM`	`BAYES`	NUTS
-2LL	X	X	X	X	X	X	X	X
`ATOL` (ADVAN9/13/14/15/16/17)	X	X	X	X	X	X	X	X
AUTO		X	X	X	X	X	X	X
BAYES_PHI_STORE							X
BIONLY							X
BOOTDATA			X	X	X	X	X	X
`CALPHA`		X	X	X	X	X	X	X
`CENTERING`	X
`CINTERVAL`		X	X	X	X	X	X	X
`CITER`/CNSAMP		X	X	X	X	X	X	X
CLOCKSEED			X	X	X	X	X	X
`CONDITIONAL`	X	X		X	X	X	X	X
CONSTRAIN						X
`CTYPE` (`CTYPE`=4)	X	X	X	X	X	X	X	X
DERCONT				X	X	X
DF			X	X	X
DFS (CHAIN only)							X
`EONLY`				X	X	X	X
ETABARCHECK	X
ETADER	X
ETASAMPLES						X
ETASTYPE	X	X		X	X	X	X	X
EVALSHRINK	X
FAST	X	X
FILE		X	X	X	X	X	X	X
FNLETA	X
FORMAT/DELIM	X	X	X	X	X	X	X	X
FPARAFILE	X
GRD		X	X	X	X	X
GRDQ				X	X
GRID (Stieltjes)	X
HYBRID	X
`IACCEPT`			X	X	X	X	X
IACCEPTL				X	X
IKAPPA							X
`INTERACTION`	X	X	X	X	X	X	X	X
`ISAMPEND`			X	X		X
`ISAMPLE`			X	X	X	X
`ISAMPLE_M1`						X	X
`ISAMPLE_M1A`						X	X
`ISAMPLE_M1B`						X	X
`ISAMPLE_M2`						X	X
`ISAMPLE_M3`						X	X
`ISCALE_MAX`				X	X	X	X
`ISCALE_MIN`				X	X	X	X
KAPPA								X
KNUTHSUMOFF	X	X	X	X	X	X	X	X
`LAPLACE`	X	X*	*	X*	*	*	*	*
LEVCENTER (for $LEVEL)	X	X	X	X	X	X	X	X
LEVOBJTYPE (for $LEVEL)	X	X	X	X	X	X	X	X
LEVWT (for `$LEVEL`)	X	X	X	X	X	X	X	X
LIKE	X	X	X	X	X	X	X	X
LNTWOPI	X	X	X	X	X	X	X	X
MADAPT								X
`MAPCOV`				X	X
MAPINTER				X	X
`MAPITER`				X	X
MAPITERS						X	X
MASSRESET							X (in prep for NUTS)	X
`MAXEVAL`	X
`MCETA`	X	X		X	X	X	X
`MSFO`	X	X	X	X	X	X	X	X
MUM		X		X	X	X	X	X
`NBURN`						X	X	X
`NITER`/NSAMPLE		X	X	X	X	X	X	X
`NOABORT`	X	X	X	X	X	X	X	X
NOCOV		X		X	X	X
NOHABORT	X (when last estimation step)	X	X	X	X	X	X	X
NOLABEL	X	X	X	X	X	X	X	X
NONINFETA	X
NOOMEGABOUNDTEST	X	X	X	X	X	X	X	X
`NOPRIOR`	X	X	X	X	X	X	X	X
NOSIGMABOUNDTEST	X	X	X	X	X	X	X	X
NOSLOW	X	X	X	X	X	X	X	X
NOSUB	X	X	X	X	X	X	X	X
NOTHETABOUNDTEST	X	X	X	X	X	X	X	X
NOTITLE	X	X	X	X	X	X	X	X
`NSIG`/`SIGDIGITS`	X	X
NUMDER	X
NUMERICAL	X	X*	*	X*	*	*	*	*
NUTS_BASE								X
NUTS_DELTA								X
NUTS_EPARAM							X (in prep for NUTS)	X
NUTS_GAMMA								X
NUTS_INIT								X
NUTS_MASS							X (in prep for NUTS)	X
NUTS_MAXDEPTH								X
NUTS_OPARAM							X (in prep for NUTS)	X
NUTS_REG							X (in prep for NUTS)	X
NUTS_SPARAM							X (in prep for NUTS)	X
NUTS_STEPINTER								X
NUTS_STEPITER								X
NUTS_TERM								X
NUTS_TEST								X
NUTS_TRANSFORM								X
`OACCEPT`							X
OLKJDF							X	X
OLNTWOPI						X	X
OMEGABOUNDTEST	X	X	X	X	X	X	X	X
OMITTED	X	X	X	X	X	X	X	X
OPTMAP	X
ORDER	X	X	X	X	X	X	X	X
`OSAMPLE_M1`							X
`OSAMPLE_M2`							X
OSAMPLE_M3							X
OVARF							X	X
`PACCEPT`							X
PARAFILE	X	X	X	X	X	X	X	X
PARAFPRINT	X	X	X	X	X	X	X	X
PHITYPE		X		X	X	X	X	X
`POSTHOC`	X	X	X	X	X	X	X	X
PREDICTION	X	X	X	X	X	X	X	X
PRINT	X	X	X	X	X	X	X	X
PRIORC	X	X	X	X	X	X	X	X
`PSAMPLE_M1`							X
`PSAMPLE_M2`							X
`PSAMPLE_M3`							X
`PSCALE_MAX`							X
`PSCALE_MIN`							X
RANMETHOD=nSmP			X	X	X	X	X	X
REPEAT	X
REPEAT1	X
REPEAT2	X
SADDLE_HESS	X
SADDLE_RESET	X
SEED			X	X	X	X	X	X
`SIGL`	X	X	X	X	X	X	X	X
SIGLO	X	X
SIGMABOUNDTEST	X	X	X	X	X	X	X	X
SLKJDF							X	X
SLOW	X	X
SORT	X
`STDOBJ`			X	X		X
STIELTJES	X
SVARF							X	X
TBLN (CHAIN only)								X
THETABOUNDTEST	X	X	X	X	X	X	X	X
THIN							X	X
TPU								X
TTDF								X
ZERO	X

*May be needed to suppress error messages from NM-TRAN or NONMEM.