Preface

This edition of “NONMEM Users Guide - Part V Introductory Guide” is distributed with NONMEM 7.6.0. It revises the version of September 2020, which appeared with NONMEM 7.5. Details that have changed since the previous edition have been corrected, and some new features have been added.

Significant changes since the previous version are marked with bars.

With this new edition, examples of NONMEM outputs have been updated to the NONMEM 7.6.0 version as needed.

True to its purpose as an instructional guide for new users of NONMEM, this Guide remains oriented to the classic NONMEM methods and basic features (through NONMEM VI). References to even earlier versions of NONMEM and PREDPP have been deleted.

Chapter 12 (Brief Descriptions of Other Features) has been revised. Sections 1-5 have been expanded to be more complete. Section 6 (“Supplemental List of Features through NONMEM 7.6.0”) is a summary of all features of NONMEM not mentioned elsewhere in this guide.

First printing of this edition is dated OCT 2024, coinciding with release of NONMEM 7.6.0.

Second printing of this edition is dated NOV 2025, and contains some corrections from the first printing.