Records marked with * may be continued. The record name, e.g., “INDX”, is not repeated on continuation(s).
FILE record (FILE) (A4,4X,A72)
| 1 |
NULL |
no file stream |
|
72 chars |
name of file stream |
SUPER record (SUPR) (A4,4X,I4,I8,I4)
| 1 |
1-9999 |
Number of problems in the superproblem |
| 2 |
2-9999 |
Number of iterations of the superproblem |
| 3 |
0 |
Input information will be printed for first problem only |
|
1 |
Input information will be printed for all problems |
PROBLEM record (PROB) (A4,4X,A72)
| 1 |
72 chars |
problem heading |
DATA record (DATA) (A4,4X,18I4)
| 1 |
0 or blank |
data set is embedded in the control stream |
|
1 |
data set is in a separate file |
|
-1 |
re-use the data set from the previous problem |
| 2 |
0 or blank |
FORTRAN unit not to be rewound |
|
1 |
FORTRAN unit to be rewound |
| 3 |
0 |
data set to be read to FINISH record or end of file |
|
1-9999 |
no. of data records (low-order digits) |
| 4 |
1-20 |
no. of data items per data record |
| 5 |
0 |
not data checkout |
|
1 |
data checkout only |
| 6 |
0-9999 |
no. of data records (high-order digits). The no. of data records is Field 6 * 10000 + Field 3. When Field 6 is 0 or blank, this is simply Field 3 |
ITEM record (ITEM) (A4,4X,18I4)
| 1 |
0-20 |
index of ID data item |
| 2 |
1-20 |
index of DV data item |
| 3 |
0-20 |
index of MDV data item |
| 4 |
0-20 |
no. of data item indices in INDXS |
| 5 |
0 |
no user-supplied labels |
|
1 |
user-supplied labels |
| 6 |
0 |
standard labels PRED, RES and WRES used |
|
1 |
nonstandard labels used |
| 7 |
0-20 |
index of L2 data item |
| 8 |
0-20 |
index of first data item specified in CONTR record |
| 9 |
0-20 |
index of second data item specified in CONTR record |
| 10 |
0-20 |
index of third data item specified in CONTR record |
| 11 |
0-50 |
no. of user-supplied labels for tables, scatters |
| 12 |
0-20 |
index of MRG_ data item |
| 13 |
0-20 |
index of RAW_ data item |
| 14 |
0-20 |
no. of items on OMIT record |
| 15 |
0-20 |
index of RPT_ data item |
INDEX record (INDX)* (A4,4X,18I4)
| 1 |
1-20 |
1st element of INDXS |
| 2 |
1-20 |
2nd element of INDXS |
|
etc. |
|
LABEL record (LABL)* (A4,4X,9(A4,4X))
| 1 |
4 chars |
label of 1st data item |
| 2 |
4 chars |
label of 2nd data item |
|
etc. |
|
| m |
4 chars |
label of last data item |
| m+1 |
4 chars |
label for PRED (if ITEM(6)=1) |
| m+2 |
4 chars |
label for RES (if ITEM(6)=1) |
| m+3 |
4 chars |
label for WRES (if ITEM(6)=1) |
| m+p+1 |
4 chars |
label for 1st variable in NMPRD4 † |
| m+p+2 |
4 chars |
label for 2nd variable in NMPRD4 † |
|
etc. |
|
| m+p+q |
4 chars |
label for last displayed variable in NMPRD4 |
Note:
- m = no. of data items per data rec. = DATA(4)
- p = 3 if non-standard labels for
PRED, RES, WRES (ITEM(6)=1)
- p = 0 otherwise
- q = no. of user supplied labels for tables, scatters = ITEM(11)
- † Blank if this variable is not displayed
OMIT record (OMIT)* (A4,4X,18I4)
| 1 |
4 chars |
no. of 1st data item omitted from template matching |
| 2 |
4 chars |
no. of 2nd data item omitted from template matching |
|
etc. |
|
FIND record (FIND) (A4,4X,18I4)
| 1 |
0 |
|
| 2 |
0 |
|
| 3 |
0 |
No Model specification file (MSFI) |
|
1 |
A Model specification file (MSFI) is to be read |
| 4 |
0 |
estimate on file not to be rescaled |
|
1 |
estimate on file to be rescaled |
| 5 |
0 |
No ONLYREAD option |
|
1 |
ONLYREAD option |
initial STRUCTURE record (STRC) (A4,4X,18I4)
| 1 |
0-70 |
length of THETA |
| 2 |
0-70 |
dimension of OMEGA |
| 3 |
0-70 |
dimension of SIGMA |
| 4 |
blank |
|
| 5 |
blank |
|
| 6 |
0 or blank |
OMEGA constrained with a block set partition |
|
1 |
OMEGA constrained to be diagonal |
| 7 |
0 or blank |
only if field 6 has value 1 |
|
1-70 |
number of block sets for OMEGA |
If the dimension of SIGMA is 0, the following fields may be ignored.
| 8 |
0 or blank |
SIGMA constrained with a block set partition |
|
1 |
SIGMA constrained to be diagonal |
| 9 |
0 or blank |
SIGMA only if field 8 has value 1 |
|
1-70 |
number of block sets for SIGMA |
| 10 |
blank |
|
| 11 |
blank |
|
| 12 |
0 or blank |
default THETA boundary test |
|
1 |
No default THETA boundary test |
| 13 |
0 or blank |
default OMEGA boundary test |
|
1 |
No default OMEGA boundary test |
| 14 |
0 or blank |
default SIGMA boundary test |
|
1 |
No default SIGMA boundary test |
STRUCTURE record for OMEGA or SIGMA (STRC/SIGMA) (A4,4X,18I4)
| 1 |
1-70 |
size of 1st. block set |
| 2 |
1-70 |
dimension of blocks in 1st. block set |
| 3 |
1-70 |
size of 2nd. block set |
| 4 |
1-70 |
dimension of blocks in 2nd. block set |
|
etc. |
|
THETA CONSTRAINT record (THCN) (A4,4X,18I4)
| 1 |
0 or blank |
THETA unconstrained |
|
1 |
THETA constrained |
| 2 |
0 or blank |
use default size of initial est. search |
|
1-9999 |
no. of points to be examined during initial est. search |
| 3 |
0 or blank |
ABORT if PRED sets error return code to 1 during search |
|
1 |
NOABORT - Ignore PRED error return code during search |
|
2 |
NOABORTFIRST - Same, even with first values |
THETA record (THTA)* (A4,4X,9A8)
| 1 |
|
initial est. of θ₁ (blank if NONMEM is to obtain the initial est.) |
| 2 |
|
initial est. of θ₂ (blank if NONMEM is to obtain the initial est.) |
|
etc. |
|
LOWER BOUND record (LOWR)* (A4,4X,9A8)
| 1 |
|
lower bound for θ₁ |
| 2 |
|
lower bound for θ₂ |
|
etc. |
|
UPPER BOUND record (UPPR)* (A4,4X,9A8)
| 1 |
|
upper bound for θ₁ |
| 2 |
|
upper bound for θ₂ |
|
etc. |
|
DIAGONAL record for OMEGA or SIGMA (DIAG)* (A4,3X,A1,9A8)
| Pos. 1 |
blank |
Not fixed |
|
1 |
Fixed |
|
2 |
NONMEM is to obtain the initial estimate(s) |
| 1 |
|
initial est. of (1,1) element of matrix |
| 2 |
|
initial est. of (2,2) element of matrix |
|
etc. |
|
BLOCK SET record for OMEGA or SIGMA (BLST)* (A4,3X,A1,9A8)
| Pos. 1 |
blank |
Not fixed |
|
1 |
Fixed |
|
2 |
NONMEM is to obtain the initial estimate(s) |
| 1 |
|
initial est. of (1,1) element of matrix |
| 2 |
|
initial est. of (1,2) element of matrix |
|
etc. |
use symmetric enumeration |
SIMULATION record (SIML) (A4,4X,18I4)
| 1 |
0 or blank |
Simulation Step implemented |
|
1 |
Simulation Step not implemented |
If the value is 1, the subsequent fields may be ignored.
| 2 |
1-10 |
no. of random sources (SORC records) |
| 3 |
0 |
eta (eps) changes with each record |
|
1 |
eta (eps) changes with new ind.rec. (L2 rec) (NEW) |
| 4 |
0-9999 |
no. of subproblems |
| 5 |
0 |
compute objective function and other steps |
|
1 |
only the simulation step |
| 6 |
0 or blank |
no partial derivatives from PRED needed |
|
1 |
PRED should compute 1st. derivatives (REQUESTFIRST) |
|
2 |
PRED should compute 2nd. derivatives (REQUESTSECOND) |
| 7 |
0 or blank |
simulated observation is Y or F (PREDICTION) |
|
1 |
simulated observation is DV (NOPREDICTION) |
| 8 |
0 or blank |
Use initial ests. (TRUE=INITIAL) |
|
1 |
with MSFI, use final ests. (TRUE=FINAL) |
|
2 |
use values in NMPR16 (TRUE=PRIOR) |
SOURCE record (SORC) (A4,4X,2A12,I4)
| 1 |
-1-21474836447 |
first seed |
| 2 |
0-21474836447 |
second seed |
| 3 |
0 or blank |
random numbers are pseudo-normal (NORMAL) |
|
1 |
random numbers are pseudo-uniform (UNIFORM) |
|
2 |
random numbers are from a nonpar. distrib (NONPARAMETRIC) |
ESTIMATION record (ESTM) (A4,4X,18I4)
| 1 |
0 or blank |
Estimation Step implemented |
|
1 |
Estimation Step not implemented |
If the value is 1, the subsequent fields may be ignored.
| 2 |
0-9999 |
maximum no. of function evaluations (low-order digits) |
|
-1 |
Reuse the value from the previous run (with MSFI) |
| 3 |
1-8 |
number of significant figs. required in final est |
| 4 |
0 or blank |
no summarization of iterations |
|
n > 0 |
every nth iteration summarized |
| 5 |
0 or blank |
no second search (REPEAT) |
|
1 |
second search (REPEAT) implemented |
| 6 |
0 or blank |
MSF not output |
|
1 |
MSF output |
| 7 |
0 or blank |
First order (FO) method |
|
1 |
Conditional method (METHOD=COND) |
| 8 |
0 or blank |
No POSTHOC etas are to be estimated |
|
1 |
POSTHOC etas are to be estimated |
| 9 |
0 or blank |
Etas are 0 for comp. of intraind. error (NOINTERACTION) |
|
1 |
Nonzero etas for comp. of intraind. error INTERACTION |
| 10 |
0 or blank |
Do not use Laplacian method |
|
1 |
Laplacian method is to be used |
| 11 |
0 or blank |
ABORT if PRED sets error return code to 1 |
|
1 |
NOABORT - Attempt theta-recovery when PRED error code 1 |
| 12 |
0 or blank |
Faster method of computation (NOSLOW) |
|
1 |
Slower method of computation (SLOW) |
|
2 |
Slower method of computation (SLOW=2); for Stieltjes |
| 13 |
0 or blank |
avg. cond. est. of etas unconstrained (NOCENTER) |
|
1 |
avg. cond. est. of etas constrained close to 0. (CENTER) |
| 14 |
0 or blank |
First-order model not used (NOFO) |
|
1 |
First-order model used with METHOD=1 CENTERING (FO) |
| 15 |
0 or blank |
Second eta-derivs. computed by PRED (NONUMERICAL) |
|
1 |
Second eta-derivs. for Laplacian to be obtained numerically |
| 16 |
0 or blank |
Y or F (with user-supplied code) is a prediction |
|
1 |
Y or F is a LIKELIHOOD |
|
2 |
Y or F is a -2LOGLIKELIHOOD |
| 17 |
0 or blank |
Not the Hybrid method |
|
1-99 |
no. of etas fixed to zero by ZERO recs. (Hybrid method) |
| 18 |
0 or blank |
Not the Stieltjes method |
|
1 |
Stieltjes method; no GRID option |
|
2 |
Stieltjes method; GRID was specified |
ESTIMATION rec. continuation rec. ( ) (A4,4X,18I4)
| 1 |
0 or blank |
Required if estimation step is omitted, otherwise: |
|
0 or blank |
The REPEAT2 option is not coded; same as NOREPEAT2 |
|
1 |
REPEAT2 (with Stieltjes) |
| 2 |
0 or blank |
No ETABARCHECK |
|
1 |
ETABARCHECK option is coded |
| 3 |
0 or blank |
Sum contrib. to obj. func. in data set order |
|
1 |
Sort contrib. to obj. func. prior to sum (SORT) |
| 4 |
0-9999 |
maximum no. of function evaluations (high-order digits). The no. of func. evals. is Field 4 * 10000 + low-order. When Field 4 is 0 or blank, this is simply low-order |
ZERO record (ZERO)* (A4,4X,18I4)
| 1 |
0 |
conditional estimate for eta(1) |
|
1 |
eta(1) is fixed to 0 (HYBRID method) |
| 2 |
0 |
conditional estimate for eta(2) |
|
1 |
eta(2) is fixed to 0 (HYBRID method) |
|
etc. |
|
GRID record (GRID) (A4,4X,9A8)
| 1 |
nr |
as specified in GRID=(nr,ns,r0,r1) |
| 2 |
ns |
as specified in GRID=(nr,ns,r0,r1) |
| 3 |
r0 |
as specified in GRID=(nr,ns,r0,r1) |
| 4 |
r1 |
as specified in GRID=(nr,ns,r0,r1) |
NONPARAMETRIC record (NONP) (A4,4X,18I4)
| 1 |
0 or blank |
Nonparametric step implemented conditionally |
|
1 |
Nonparametric step implemented unconditionally |
| 2 |
0 or blank |
use nonparametric estimate from input MSF |
|
1 |
recompute nonparametric estimate |
| 3 |
0 or blank |
obtain marginal cumulatives |
|
1 |
compute conditional nonpar. etas (CNPE ETAS) |
| 4 |
0 or blank |
no model specification file is output |
|
1 |
a model specification file is output |
COVARIANCE record (COVR) (A4,4X,18I4)
| 1 |
0 or blank |
Covariance Step conditionally implemented |
|
(1) |
(Covariance Step unconditionally implemented — obsolete) |
|
2 |
Covariance Step not implemented |
| 2 |
0 or blank |
covariance matrix set to (R inverse) S (R inverse) |
|
1 |
covariance matrix set to R inverse |
|
2 |
covariance matrix set to S inverse |
| 3 |
0 or blank |
neither R nor S printed |
|
1 |
R matrix printed |
|
2 |
S matrix printed |
|
3 |
both R and S printed |
| 4 |
0 or blank |
eigenvalues not printed |
|
1 |
eigenvalues printed |
| 5 |
0 or blank |
default computation |
|
1 |
Special computation with a recursive PRED subroutine |
| 6 |
0 or blank |
Print Covariance Step arrays in normal format |
|
1 |
Print Covariance Step arrays in compressed format |
| 7 |
1 |
|
| 8 |
0 or blank |
|
| 9 |
0 or blank |
Normal method of computation |
|
1 |
Slower method of computation (SLOW) |
initial TABLE record (TABL) (A4,4X,18I4)
| 1 |
0 or blank |
Table Step conditionally implemented |
|
1 |
Table Step unconditionally implemented |
|
2 |
Table Step not implemented |
If the value is 2, the next field may be ignored, and there should not appear any individual TABLE records.
individual TABLE record (TABL) (A4,3X,I1,18I4)
| Pos. 1 |
blank |
no option record |
|
1 |
an option record follows (only if at least one item on the option rec. is non-blank) |
| 1 |
0-50 |
number of selected data item types |
| 2 |
1-999 |
index of 1st selected data item type |
| 3 |
0-8 |
sort code for data items of 1st selected type |
| 4 |
1-999 |
index of 2nd selected data item type |
| 5 |
0-8 |
sort code for data items of 2nd selected type |
|
etc. |
|
individual TABLE rec. contin. rec. ( )* (A4,4X,18I4)
(as needed)
| 1 |
1-999 |
index of 9th. selected data item type |
| 2 |
0 |
|
| 3 |
1-999 |
index of 10th. selected data item type |
| 4 |
0 |
|
|
etc. |
|
individual TABLE record option rec. ( ) (A4,4X,18I4)
| 1 |
blank |
Every data record appears in the table |
|
1 |
Only the first data rec. from each ind. rec. (FIRSTONLY) |
| 2 |
1 |
With TABLE file, no printed table (NOPRINT) |
|
2 |
With TABLE file, printed table appears in the NONMEM output |
| 3 |
blank |
Normal header lines appear in the TABLE file |
|
1 |
Only one header in the TABLE file (ONEHEADER) |
|
2 |
No headers are included in the TABLE file (NOHEADER) |
| 4 |
blank |
The TABLE file is opened and is positioned at the start |
|
1 |
The TABLE file is positioned at the end (FORWARD) |
| 5 |
blank |
DV, PRED, RES, WRES appear automatically |
|
1 |
DV, PRED, RES, WRES do not appear unless listed (NOAPPEND) |
initial SCATTERPLOT record (SCAT) (A4,4X,18I4)
| 1 |
0 or blank |
Scatterplot Step conditionally implemented |
|
1 |
Scatterplot Step unconditionally implemented |
|
2 |
Scatterplot Step not implemented |
If the value is 2, the next field may be ignored, and there should not appear any individual SCATTERPLOT records.
| 2 |
1-20 |
number of families |
individual SCATTERPLOT record (SCAT) (A4,4X,6I4,2I8,4I4,16X)
| 1 |
1-23 |
index of data items plotted on abscissa axis |
| 2 |
1-23 |
index of data items plotted on ordinate axis |
| 3 |
0 or blank |
a single scatterplot |
|
1 |
a one-way partitioned scatterplot |
|
2 |
a two-way partitioned scatterplot |
If the value of field 3 is 0 or blank, the next two fields should be ignored.
| 4 |
1-23 |
index of 1st separator |
If the value of field 3 is 1, the next field should be ignored.
| 5 |
1-23 |
index of 2nd separator |
| 6 |
0 or blank |
no unit slope line appears |
|
1 |
unit slope line appears |
| 7 |
0-99999999 |
no. of the first data rec. for the scatter (FROM) |
| 8 |
0-99999999 |
no. of the last data rec. for the scatter (TO) |
| 9 |
0 or blank |
a line through zero on the ordinate axis if appropriate |
|
1 |
a line through zero on the ordinate axis. (ORD0) |
|
-1 |
no line through zero on the ordinate axis |
| 10 |
0 or blank |
a line through zero on the abscissa axis if appropriate |
|
1 |
a line through zero on the abscissa axis. (ABS0) |
|
-1 |
no line through zero on the abscissa axis |
| 11 |
0 or blank |
Every data record appears in the scatter |
|
1 |
Only the first data rec. from each ind. rec. (FIRSTONLY) |
| 12 |
0 or blank |
Every data record appears in the scatter |
|
1 |
Only data records with MDV=0 (OBSONLY) |