Preface

The NONMEM Installation Guide contains more details on NONMEM installation than are needed by most users. If NONMEM is to be installed under Microsoft Windows/MS-DOS or Unix/Linux/OS X, look first at the README_760 document on the CD. It describes an easy installation using SETUP76.BAT (for Windows/MS-DOS) and SETUP76 (for Unix/Linux/OS X).

All files are distributed on a single CD. There is no single-precision version of NONMEM 7. You must replace all of NONMEM, PREDPP, and NM-TRAN. Do not mix new and old versions of the various components of the NONMEM system!

The MS-DOS installation utility is now called SETUP76.BAT. The UNIX installation utility is called SETUP76. UNIX shell scripts NMFE76 and MS-DOS batch file NMFE76.BAT are used to run NONMEM 7.6. They both have an option “recompile” that allows the source code to be recompiled easily after a change to SIZES.

There is a single INCLUDE file named SIZES.f90. This file contains all the constants pertaining to NM-TRAN, NONMEM, and PREDPP. Many of the constants can be changed with the $SIZES record in a control stream file, although still some require modification in SIZES.f90, and recompilation of the NM-TRAN and NONMEM system.

When re-running old NONMEM problems, please be aware of the following facts:

NONMEM output changes slightly with each version.

It is possible that the results of the Estimation and Covariance Steps may be different than with earlier versions of NONMEM.

Old Model Specification files (MSF’s) cannot be re-used with a new release.

Old F77 Fortran subroutines (e.g., PRED, MODEL, PK, DES, AES routines) (whether user-coded or generated by NM-TRAN) cannot be re-used without certain modifications into F90 format.

Old NM-TRAN control streams and NM-TRAN data files can be re-used. Old NONMEM data files can be re-used.

In general, we have tried to make NONMEM 7.6 upwards compatible from earlier versions of NONMEM 7.

In the hardcopy and pdf versions of this guide, significant changes to the content versus the NONMEM 7.5 have been made. The appropriate citation to use for the NONMEM software and these guides is:

Beal SL, Sheiner LB, Boeckmann AJ, and Bauer RJ (eds) NONMEM 7.6.0 Users Guides. (1989–2024). ICON plc, Blue Bell, PA. https://nonmem.iconplc.com/nonmem760