90  Obtaining random samples of individual predicted values and individual parameters during MCMC Bayesian Analysis

Introduction to NONMEM 7.6.0

Usually it is enough to obtain the population parameters THETAs, OMEGAs, and SIGMAs for each accepted sample, which is listed in the raw output file specified by FILE= of the $EST command. Occasionally one wishes to obtain a distribution of individual parameters, or even predicted values. This is done be incorporating additional verbatim code. This is best shown by example 8. The BAYES_EXTRA_REQUEST is set to 1, informing NONMEM that PRED/PK/ERROR are to be called after an example has been accepted. The sample is indicated as accepted when NONMEM sets BAYES_EXTRA to 1. An IF block can be written by the user to, for example, write the individual parameters in a separate file (as shown in example 8), or the user may simply desire to obtain the minimum, maximum values obtained.