Appendix

Appendix I. NM-TRAN Control Records

Listed are some of the options available for some of the most-used NMTRAN records. Guide VIII has the complete list of records and description of options.

$SIZES

$SUPERPROBLEM

$PROBLEM  text

$INPUT item₁  item₂  item₃ · · ·

$INDEX  [label₁|value₁]  [label₂|value₂]  [label₃|value₃] ...

$CONTR    DATA= ([label₁|0] [label₂|0] [label₃|0])

$DATA  [filename|*] [(format)] [IGNORE=c₁] [NULL=c₂] [NOWIDE|WIDE] [CHECKOUT]
       [RECORDS=n₁] [LRECL=n₂] [NOREWIND|REWIND]

$SUBROUTINES  [subname₁ = name₁]  [subname₂ = name₂] ...
              [SUBROUTINES=kind]

$ABBREVIATED [COMRES=n₁] [COMSAV=n₂] [DERIV2=NO] [DERIV2=NOCOMMON]

$PRED
    the abbreviated code

$THETA value₁  [value₂]  [value₃] ...
       [NUMBERPOINTS=n] [ABORT|NOABORT]

$OMEGA [DIAGONAL(n)|BLOCK(n)|BLOCK(n) SAME|BLOCK SAME]
       [[value₁] [value₂] [value₃] ... [FIXED]]

$SIGMA [DIAGONAL(n)|BLOCK(n)|BLOCK(n) SAME|BLOCK SAME]
       [[value₁] [value₂] [value₃] ... [FIXED]]

$MSFI filename [NORESCALE|RESCALE] [NPOPETAS=n]

$SIMULATION (seed1 [seed2] [NORMAL|UNIFORM] [NEW]) ...
            [SUBPROBLEMS=n] [ONLYSIMULATION] [OMITTED]

$ESTIMATION [METHOD=kind] [NOINTERACTION|INTERACTION] [NOLAPLACIAN|LAPLACIAN]
            [NOPOSTHOC|POSTHOC] [SIGDIGITS=n₁] [MAXEVALS=n₂] [PRINT=n₃]
            [ABORT|NOABORT] [MSFO=filename] [NOREPEAT|REPEAT] [OMITTED]

$COVARIANCE [SPECIAL] [MATRIX=c] [PRINT=[E][R][S]]
            [CONDITIONAL|UNCONDITIONAL] [OMITTED]

$TABLE [list1] [BY list2] [PRINT|NOPRINT] [FILE=filename] [NOHEADER|ONEHEADER]
       [UNCONDITIONAL|CONDITIONAL] [OMITTED]

$SCATTERPLOT  list1  VS  list2  [BY list3]
              [UNIT] [ORD0] [FROM n₁] [TO n₂]
              [UNCONDITIONAL|CONDITIONAL] [OMITTED]

$INCLUDE filename [n]

Appendix II. NM-TRAN Data Set – Example

Here is a NM-TRAN data set which NM-TRAN translates into a NONMEM data set shown in Appendix III. The NONMEM data set in Appendix III is identical to that shown in Figure 75 of NONMEM Users Guide, Part I, except for spacing between fields. This NM-TRAN data set is recorded on the NONMEM distribution medium as file THEO; see Guide III.

     1       4.02       0.         .74      79.6
     1         .        0.25       2.84        .
     1         .        0.57       6.57        .
     1         .        1.12       10.5        .
     1         .        2.02       9.66        .
     1         .        3.82       8.58        .
     1         .        5.1        8.36        .
     1         .        7.03       7.47        .
     1         .        9.05       6.89        .
     1         .       12.12       5.94        .
     1         .       24.37       3.28        .
     2       4.4        0.         0.        72.4
     2         .         .27       1.72        .
     2         .         .52       7.91        .
     2         .        1.         8.31        .
     2         .        1.92       8.33        .
     2         .        3.5        6.85        .
     2         .        5.02       6.08        .
     2         .        7.03       5.4         .
     2         .        9.         4.55        .
     2         .       12.         3.01        .
     2         .       24.3         .90        .

The data set continues with data for subjects 3-12 (see the original PDF for the complete data set). The columns are ID, DOSE, TIME, CP, and WT (weight).

Appendix III. NM-TRAN Outputs – Example

The NM-TRAN outputs obtained from using the NM-TRAN control stream listed in chapter I, along with the NM-TRAN data set listed in Appendix II, are described in this appendix. Some code that is extraneous to the control stream was removed from SUBROUTINE PRED for the purposes of simplicity.

Data Set - FDATA

The NONMEM data set is substantially similar to the NM-TRAN data set, but with a standardized format. The subjects 1-12 appear in sequence with their respective dose and observation records.

Control Stream - FCON

FILE    FSTREAM
PROB    THEOPHYLLINE    POPULATION DATA
FMTN    3
LDFO    0
DATA       1   0 132   5   0   0   0   0          -1  0 0
ITEM       1   4   0   0   1   0   0   0   0   0   0   0   0   0   0   0
XVID       0   0   0   0   0
MSDT    0.00000000000000E+000
LABL                               ID,                           DOSE
                                   TIME,                         CP
                                   WT
LBW1 IWRS,IPRD
     IRS,NPRED
     NRES,NWRES
     NIWRES,NIPRED
     NIRES,CPRED
     CRES,CWRES
     CIWRES,CIPRED
     CIRES,PREDI
     RESI,WRESI
     IWRESI,IPREDI
     IRESI,CPREDI
     CRESI,CWRESI
     CIWRESI,CIPREDI
     CIRESI,EPRED
     ERES,EWRES
     EIWRES,EIPRED
     EIRES,NPDE
     ECWRES,NPD
     OBJI
LRES SIGMA
LTHT
LETA
LEPS
FORM
(5E6.0)
STRC    3   3   1   0   0   0   1   1   0
STRC    1   3
THCN    1   0   0   0
THTA    3.000000000000000E+00, 8.000000000000000E-02, 4.000000000000000E-02
THTU    0,0,0
LOWR    1.000000000000000E-01, 8.000000000000000E-03, 4.000000000000000E-03
UPPR    5.000000000000000E+00, 5.000000000000000E-01, 9.000000000000000E-01
BLST    6.000000000000000E+00, 5.000000000000000E-03, 3.000000000000000E-01
        2.000000000000000E-04, 6.000000000000000E-03, 4.000000000000000E-01
DIAG    4.000000000000000E-01
DFLT    -1
ESTM       0 450   3   5   0   0   0   0   0   0   0   0   0   0   0   0   0
           0   0   0   0  -1  -1   0   0   0
(... BEST vector, COVR, TABL, SCAT records follow ...)

File Stream - FSTREAM

DATA    FDATA
****

Report - FREPORT

NM-TRAN VERSION 7.6.0
GENERATED DP SUBROUTINES:
PRED
NONMEM SUBROUTINES: ALL

Generated Subroutine - FSUBS (PRED)

      SUBROUTINE PRED  (ICALL,NEWIND,THETA,DATREC,INDXS,F,G,H)
      USE NMPRD4P
      USE SIZES,      ONLY: DPSIZE,ISIZE
      USE PRDIMS,     ONLY: GPRD,HPRD,GERD,HERD,GPKD
      USE NMBAYES_REAL,    ONLY: PRIOR_INFO
      USE NM_BAYES_INT, ONLY: TOLTOPRED
      USE NMPRD_INT,  ONLY: PRED_IGNORE_DATA,PRED_IGNORE_DATA_TEST
      USE NMPRD_REAL,ONLY: ETA,EPS
      USE NMPRD_INT,  ONLY: MSEC=>ISECDER,MFIRST=>IFRSTDER,IFIRSTEM
      USE NMPRD_INT,  ONLY: MDVRES,ETASXI,NPDE_MODE,NOFIRSTDERCODE
      USE NMPRD_REAL, ONLY: DV_LOQ,CDF_L,DV_LAQ,CDF_LA
      USE NMPRD_INT,  ONLY: NEWL2
      USE NMBAYES_REAL, ONLY: LDF
      USE NMBAYES_INT, ONLY: FLDF
      IMPLICIT REAL(KIND=DPSIZE) (A-Z)
      REAL(KIND=DPSIZE) :: DATREC
      SAVE
      INTEGER(KIND=ISIZE) :: ICALL,NEWIND,INDXS
      REAL(KIND=DPSIZE) :: G(GPRD,*),H(HPRD,*)
      DIMENSION :: THETA(*),DATREC(*),INDXS(*)
      INTEGER(KIND=ISIZE) :: FIRSTEM
      IF(ICALL==0.AND.TOLTOPRED==1) RETURN
      FIRSTEM=IFIRSTEM
      IF (ICALL <= 1) CALL ASSOCNMPRD4
      IF (ICALL == 4) THEN
      IF (NEWIND /= 2) THEN
      CALL SIMETA(ETA)
      IF (IQUIT == 1) RETURN
      ENDIF
      IF (NEWL2 == 1) THEN
      CALL SIMEPS(EPS)
      IF (IQUIT == 1) RETURN
      ENDIF
      ELSE
      IF (NEWIND /= 2) THEN
      CALL GETETA(ETA)
      IF (IQUIT == 1) RETURN
       EPS(001)=0.D0
      ENDIF
      ENDIF
      DOSE=DATREC(002)
      TIME=DATREC(003)
      WT=DATREC(005)
      IF(DOSE /= 0.D0)THEN
      DS=DOSE*WT
      W=WT
      ENDIF
      KA=THETA(001)+ETA(001)
      KE=THETA(002)+ETA(002)
      CL=THETA(003)*W+ETA(003)
      B000005=-KE*TIME
      B000006=-KA*TIME
      B000007=DEXP(B000005)
      B000008=DEXP(B000006)
      D=B000007-B000008
      B000009=KA-KE
      E=CL*B000009
      F=DS*KE*KA/E*D
      Y=F+EPS(001)
      C000031=1.D0
      IF (FIRSTEM == 1) THEN !1
      A000034=-TIME
      A000035=-TIME
      A000036=B000007*A000034
      A000037=B000008*A000035
      A000039=-A000037
      A000041=-1.D0
      A000043=CL*A000041
      B000011=DS*KA/E*D
      B000012=DS*KE/E*D
      B000013=-DS*KE*KA/E/E*D
      A000048=B000013*CL+B000012
      A000049=B000013*A000043+B000011
      A000050=B000013*B000009
      B000014=DS*KE*KA/E
      A000051=B000014*A000039+A000048
      A000052=B000014*A000036+A000049
      A000060=A000052
      A000061=A000051
      A000062=A000050
      G(001,1)=A000061
      G(002,1)=A000060
      G(003,1)=A000062
      ENDIF !1
      H(001,1)=C000031
      IF (FIRSTEM == 1) THEN !2
      ENDIF !2
      F=Y
      RETURN
      END

Appendix IV. Another Example

Figures 1 and 2 of NONMEM Users Guide, Part I, show a PRED routine and a NONMEM control stream (with embedded data), respectively. The NONMEM outputs resulting from Figures 1 and 2 are shown in Figures 3-18 of Part I. NM-TRAN inputs and outputs are given below. The inputs correspond to Figures 1 and 2. The NONMEM outputs resulting from the NM-TRAN outputs and corresponding to those shown in Figures 4-18 are exactly the same as those shown in Figures 4-18. The NONMEM output corresponding to that shown in Figures 3a-b, the problem summary, is a little different (in part because NM-TRAN generates ID data items).

NM-TRAN Data Set

     320         .27       1.71
     320         .52       7.91
     320        1.         8.31
     320        1.92       8.33
     320        3.5        6.85
     320        5.02       6.08
     320        7.03       5.4
     320        9.         4.55
     320       12.         3.01
     320       24.3         .90

NM-TRAN Control Stream

$PROB    SIMPLE NONLINEAR REGRESSION OF CP VS TIME DATA FROM ONE SUBJECT
$INPUT        DOSE TIME CP=DV
$DATA         DATA

$PRED
;THETA(1)=ABSORPTION RATE CONSTANT (1/HR)
;THETA(2)=ELIMINATION RATE CONSTANT (1/HR)
;THETA(3)=VOLUME OF DISTRIBUTION (LITERS)
   D=EXP(-THETA(2)*TIME)-EXP(-THETA(1)*TIME)
   E=THETA(3)*(THETA(1)-THETA(2))
   F=DOSE*THETA(1)/E*D
   Y=F+ETA(1)

$THETA   (.4,1.7,7.)  (.025,.102,.4)  (10,29,80)

$EST      MAXEVAL=240 SIGDIGITS=4 PRINT=2
$COV
$TABLE        TIME
$SCAT         (CP PRED RES) VS TIME
$SCAT         PRED VS CP   UNIT

NONMEM Data Set - FDATA

NONMEM data records include the generated .ID. column (values alternating 1 and 2):

320  .27 1.71 1
320  .52 7.91 2
320   1. 8.31 1
320 1.92 8.33 2
320  3.5 6.85 1
320 5.02 6.08 2
320 7.03  5.4 1
320   9. 4.55 2
320  12. 3.01 1
320 24.3  .90 2

Appendix V. NM-TRAN Control Records with PREDPP

$PROBLEM  text

$INPUT item₁  item₂  item₃ · · ·

$BIND value₁ value₂ ... valueₙ

$INDEX [label₁|value₁] [label₂|value₂] [label₃|value₃] ...

$CONTR    DATA= ([label₁|0] [label₂|0] [label₃|0])

$DATA  [filename|*] [(format)] [IGNORE=c₁] [NULL=c₂] [NOWIDE|WIDE] [CHECKOUT]
       [RECORDS=n₁] [LRECL=n₂] [NOREWIND|REWIND]

$SUBROUTINES  [subname₁ = name₁]  [subname₂ = name₂] ...
              [SUBROUTINES=kind] [TOL=n₁]

$MODEL  [NCOMPARTMENTS=n₁] [NEQUILIBRIUM=n₂] [NPARAMETERS=n₃]
        [COMPARTMENT=([name] [attribute₁] [attribute₂] ...)] ...
        [LINK compnameₐ [TO|AND] compnameᵦ BY k [l]] ...

$ABBREVIATED [COMRES=n₁] [COMSAV=n₂] [DERIV2=NO] [DERIV2=NOCOMMON]

$PK
    abbreviated code

$ERROR
    abbreviated code

$DES
    abbreviated code

$AESINITIAL
    abbreviated code

$AES
    abbreviated code

$TOL
    abbreviated code

$THETA value₁ [value₂] [value₃] ...
       [NUMBERPOINTS=n] [ABORT|NOABORT]

$OMEGA [DIAGONAL(n)|BLOCK(n)|BLOCK(n) SAME|BLOCK SAME]
       [[value₁] [value₂] [value₃] ... [FIXED]]

$SIGMA [DIAGONAL(n)|BLOCK(n)|BLOCK(n) SAME|BLOCK SAME]
       [[value₁] [value₂] [value₃] ... [FIXED]]

$MSFI filename [NORESCALE|RESCALE] [NPOPETAS=n]

$SIMULATION (seed1 [seed2] [NORMAL|UNIFORM] [NEW]) ...
            [SUBPROBLEMS=n] [ONLYSIMULATION] [OMITTED]

$ESTIMATION [METHOD=kind] [NOINTERACTION|INTERACTION] [NOLAPLACIAN|LAPLACIAN]
            [NOPOSTHOC|POSTHOC] [SIGDIGITS=n₁] [MAXEVALS=n₂] [PRINT=n₃]
            [ABORT|NOABORT] [MSFO=filename] [NOREPEAT|REPEAT] [OMITTED]

$COVARIANCE [SPECIAL] [MATRIX=c] [PRINT=[E][R][S]]
            [CONDITIONAL|UNCONDITIONAL] [OMITTED]

$TABLE  [list1] [BY list2] [PRINT|NOPRINT] [FILE=filename] [NOHEADER|ONEHEADER]
        [UNCONDITIONAL|CONDITIONAL] [OMITTED]

$SCATTERPLOT  list1 VS list2 [BY list3]
              [UNIT] [ORD0] [FROM n₁] [TO n₂]
              [UNCONDITIONAL|CONDITIONAL] [OMITTED]

Appendix VI. NM-TRAN Data Set with PREDPP – Example

Here is a NM-TRAN data set which NM-TRAN translates into a NONMEM data set shown in Appendix VII. The NONMEM data set in Appendix VII is identical to that shown in Appendix II of NONMEM Users Guide, Part VI, except for spacing between columns. This NM-TRAN data set is recorded on the NONMEM distribution medium; see Guide III.

For each subject, the first row has dose amount and body weight; subsequent rows have time and concentration observations:

     1       4.02       0.         .        79.6
     1         .        0.         .74         .
     1         .        0.25       2.84        .
     1         .        0.57       6.57        .
     1         .        1.12       10.5        .
     1         .        2.02       9.66        .
     1         .        3.82       8.58        .
     1         .        5.1        8.36        .
     1         .        7.03       7.47        .
     1         .        9.05       6.89        .
     1         .       12.12       5.94        .
     1         .       24.37       3.28        .
     2       4.4        0.         .        72.4
     2         .        0.         0.          .
     2         .         .27       1.72        .
     ...

The data set continues with data for subjects 2-12. The columns are ID, DOSE (AMT), TIME, CP (DV), and WT.

Appendix VII. NM-TRAN Outputs with PREDPP – Example

The NM-TRAN outputs obtained from using the NM-TRAN control stream listed in chapter V, along with the NM-TRAN data set listed in Appendix VI, are given below.

Data Set - FDATA

NONMEM data records include EVID and MDV columns. For example:

 1  4.02  0.         79.6  1  1
 1        0.    .74        0  0
 1        0.25   2.84      0  0
 1        0.57   6.57      0  0
 ...

Report - FREPORT

NM-TRAN VERSION 7.6.0
SUBROUTINES FROM THE PREDPP LIBRARY:
PRED   PREDI  CHECK   SADVAN  ADVAN2   SSS0    TRANS1   INFN
GENERATED DP SUBROUTINES:
PK     ERROR
NONMEM SUBROUTINES: ALL

Generated Subroutines - FSUBS

Generated PK subroutine (excerpt):

      SUBROUTINE PK(ICALL,IDEF,THETA,IREV,EVTREC,NVNT,INDXS,IRGG,GG,NETAS)
      USE NMPRD4P
      USE SIZES,      ONLY: DPSIZE,ISIZE
      USE PRDIMS,     ONLY: GPRD,HPRD,GERD,HERD,GPKD
      USE NMBAYES_REAL,    ONLY: PRIOR_INFO
      USE NMBAYES_REAL, ONLY: ADDL_ACTUAL,ADDL_TIMEDIFF,ADDL_TIME
      USE NMPRD_INT,  ONLY: PRED_IGNORE_DATA,PRED_IGNORE_DATA_TEST
      USE PRCOM_INT,  ONLY: DES_DER=>MITER
      USE NMPRD_REAL,ONLY: ETA,EPS
      USE NMPRD_INT,  ONLY: MSEC=>ISECDER,MFIRST=>IFRSTDER,COMACT,COMSAV,IFIRSTEM,FIRSTEM
      ...
      IMPLICIT REAL(KIND=DPSIZE) (A-Z)
      REAL(KIND=DPSIZE) :: EVTREC
      SAVE
      INTEGER(KIND=ISIZE) :: ICALL,IDEF,IREV,NVNT,INDXS,IRGG,NETAS
      DIMENSION :: IDEF(7,*),THETA(*),EVTREC(IREV,*),INDXS(*),GG(IRGG,GPKD+1,*)
      FIRSTEM=IFIRSTEM
      IF (ICALL <= 1) THEN
      CALL ASSOCNMPRD4
      IDEF(1,0001) = -9
      IDEF(1,0002) = 1
      IDEF(1,0003) = 0
      IDEF(1,0004) = 0
      IDEF(2,0003) = 0
      IDEF(2,0004) = 0
      IDEF(3,0002) = 4
      CALL GETETA(ETA)
      IF (IQUIT == 1) RETURN
      RETURN
      ENDIF
      IF (NEWIND /= 2) THEN
      IF (ICALL == 4) THEN
      CALL SIMETA(ETA)
      ELSE
      CALL GETETA(ETA)
      ENDIF
      IF (IQUIT == 1) RETURN
      ENDIF
      WT=EVTREC(NVNT,005)
      KA=THETA(001)+ETA(001)
      K=THETA(002)+ETA(002)
      CL=THETA(003)*WT+ETA(003)
      SC=CL/K/WT
      IF (FIRSTEM == 1) THEN
      A000031=1.D0
      A000032=1.D0
      B000001=1.D0/K/WT
      A000034=B000001
      B000002=-CL/K/K/WT
      A000035=B000002*A000032
      GG(0001,1,1)=K
      GG(0001,0003,1)=A000032
      GG(0003,1,1)=KA
      GG(0003,0002,1)=A000031
      GG(0004,1,1)=SC
      GG(0004,0003,1)=A000035
      GG(0004,0004,1)=A000034
      ELSE
      GG(0001,1,1)=K
      GG(0003,1,1)=KA
      GG(0004,1,1)=SC
      ENDIF
      RETURN
      END

Generated ERROR subroutine (excerpt):

      SUBROUTINE ERROR (ICALL,IDEF,THETA,IREV,EVTREC,NVNT,INDXS,F,G,HH)
      USE NMPRD4P
      USE SIZES,      ONLY: DPSIZE,ISIZE
      ...
      IF (ICALL <= 1) THEN
      CALL ASSOCNMPRD4
      IDEF(2)=2
      HH(1,1)=1.0D0
      IDEF(3)=000
      RETURN
      ENDIF
      IF (ICALL == 4) THEN
      IF (NEWL2 == 1) THEN
      CALL SIMEPS(EPS)
      IF (IQUIT == 1) RETURN
      ENDIF
      ENDIF
      Y=F+EPS(001)
      IF (FIRSTEM == 1) THEN !1
      ENDIF !1
      F=Y
      RETURN
      END

Appendix VIII. Additional NM-TRAN Control Streams

The NM-TRAN control stream listed in chapter V specifies that ADVAN2 be used. The results from NONMEM-PREDPP, using this control stream along with the NM-TRAN data set listed in Appendix VI, can be essentially duplicated, using NM-TRAN control streams which specify different ADVAN’s, but which name the same data set. Two such control streams are given here, one specifying ADVAN7 and the other specifying ADVAN6. The two control streams are recorded on the NONMEM distribution medium; see Guide III.

NM-TRAN Control Stream Specifying ADVAN7

$PROB    THEOPHYLLINE    POPULATION DATA
$INPUT      ID DOSE=AMT TIME CP=DV WT
$DATA       THEOPP

$SUBROUTINES  ADVAN7
$MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) COMP=(CENTRAL,DEFOBS,NOOFF)

$PK
;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
;SCALING PARAMETER=VOLUME/WT SINCE DOSE IS WEIGHT-ADJUSTED
   CALLFL=1
   K12=THETA(1)+ETA(1)
   K20=THETA(2)+ETA(2)
   CL=THETA(3)*WT+ETA(3)
   S2=CL/K20/WT

$THETA   (.1,3,5) (.008,.08,.5) (.004,.04,.9)
$OMEGA BLOCK(3)  6 .005 .0002 .3 .006 .4

$ERROR
   Y=F+EPS(1)

$SIGMA   .4

$EST     MAXEVAL=450  PRINT=5
$COV
$TABLE         ID DOSE WT TIME
$SCAT          (RES WRES) VS TIME BY ID

NM-TRAN Control Stream Specifying ADVAN6

$PROB    THEOPHYLLINE    POPULATION DATA
$INPUT      ID DOSE=AMT TIME CP=DV WT
$DATA       THEOPP

$SUBROUTINES  ADVAN6  TOL=5
$MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) COMP=(CENTRAL,DEFOBS,NOOFF)

$PK
;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
;SCALING PARAMETER=VOLUME/WT SINCE DOSE IS WEIGHT-ADJUSTED
   CALLFL=1
   KA=THETA(1)+ETA(1)
   KE=THETA(2)+ETA(2)
   CL=THETA(3)*WT+ETA(3)
   S2=CL/KE/WT

$THETA   (.1,3,5) (.008,.08,.5) (.004,.04,.9)
$OMEGA BLOCK(3)  6 .005 .0002 .3 .006 .4

$DES
   DADT(1)=-KA*A(1)
   DADT(2)= KA*A(1)-KE*A(2)

$ERROR
   Y=F+EPS(1)

$SIGMA   .4

$EST     MAXEVAL=450  PRINT=5
$COV
$TABLE         ID DOSE WT TIME
$SCAT          (RES WRES) VS TIME BY ID

Appendix IX. Another Example with PREDPP

Figures 7, 11, and 25 of NONMEM Users Guide, Part VI, show a PK routine, an ERROR routine and a NONMEM control stream (with embedded data), respectively. Problem summary pages from NONMEM and PREDPP, resulting from Figures 7, 11, and 25 are shown in Figures 27-28 of Part VI. NM-TRAN inputs and outputs correspond to Figures 7, 11, and 25. The resulting problem summary page from NONMEM is just a little different from that shown in Figure 27 of Part VI due to the fact that NM-TRAN generates EVID, MDV and ID data items. The NM-TRAN data set and control stream are recorded on the NONMEM distribution medium; see Guide III.