15 How to Read the NONMEM Distribution Medium
This chapter describes the contents of NONMEM distribution medium, and describes how to read the files.
1 Media Characteristics
NONMEM source code, On-line Help files, and Users Guides are distributed on a single CD. Only one version of NONMEM is distributed. Changes to the source code should not be required to specialize it to a particular computer system.
2 Contents of the Distribution Medium
2.1 Top Directory
These files provide scripts and executables that are needed for installing NONMEM in several environments.
BuildEnvironmentWindowforNONMEM.pdf
install_Darwin
install_Darwin_32
install_darwin_32.txt
install_Darwin_powerpc
install_Linux
install_SunOS
install_SunOS_i386
install_Win.exe
intro7.pdf (same as nm760.pdf)
NONMEM-PDx-Pop-Support.pdf
nonmem.lic
readme_760.pdf
SETUP76
SETUP76.bat
unzip.exe
unzip.SunOS2.2 compilers
Compilers are no longer distributed with the NONMEM distribution medium, but are located on:
https://nonmem.iconplc.com/nonmem7/compilers/
Further information about compilers can be found in readme_760.pdf
2.3 mpich2
Installers for mpich2 are no longer on the distribution medium, but can be found at
https://nonmem.iconplc.com/mpich2
In addition, materials for installing Microsoft MPI for Windows are located at:
https://nonmem.iconplc.com/msmpi
Further information about MPI can be found in readme_760.pdf.
2.4 NONMEM_7.6.x
guides.zip
help.zip
html.zip
nonmem76e.zip
nonmem76r.zip2.5 guides.zip
The zip file guides.zip contains all parts of the NONMEM Users Guide as PDF files. These files may be searched and displayed on-line. They may also be printed.
| Name of Documentation | Description/Title | On this site |
|---|---|---|
| I.pdf | Users Basic Guide. A step by step discussion of various NONMEM features and statistical concepts involved in using NONMEM. Of historical interest for early versions of NONMEM. Part V should be read first. | Part I |
| II.pdf | Users Supplemental Guide. A continuation of Part I which includes some special features of NONMEM. | Part II |
| III.pdf | NONMEM 7.6 Installation Guide | Part III |
| IV.pdf | NM-TRAN Guide. A complete reference guide to NM-TRAN (which includes the Data Preprocessor). | Part IV |
| V.pdf | Introductory Guide. A guide for beginning users of NM-TRAN/NONMEM-PREDPP. A NONMEM user should read the Introductory Guide first. | Part V |
| VI.pdf | PREDPP Guide. A complete reference guide to PREDPP. | Part VI |
| VII.pdf | Conditional Estimation Methods. A description of these methods and some guidelines for their use. | Part VII |
| VIII.pdf | Help Guide. A fast way to locate information on a given word or topic. The content of the Help Guide is also supplied on the NONMEM distribution medium for on-line use. | Part VIII |
| nm760.pdf (intro7.pdf) | Introduction To Nonmem 7.6.0. Describes changes from NONMEM VI Release 2.0, to 7.1.0, 7.1.2, 7.2.0, 7.3.0, 7.4.1, 7.4.2, 7.4.3, 7.4.4, 7.5.0, 7.5.1, and 7.6.0. | Intro to NONMEM v7 |
| Supp.pdf | NONMEM V Supplemental Guide. Describes changes found with NONMEM V of which the user should be aware, especially if he used earlier versions of NONMEM. | NONMEM V Supplement |
| Intro.pdf | Introduction to Version VI. Describes changes and new features found with NONMEM VI of which the user should be aware, especially if he used earlier versions of NONMEM. | Intro to NONMEM v6 |
| Readme_760.pdf | NONMEM760 Release Memo. The NONMEM Distribution medium contains files readme_760.pdf (The names may change with future releases.) The “.pdf” file may be viewed with Adobe Acrobat Reader. You may print it. Their content is identical with chapter IV of this installation guide. The “readme” contains important information that was developed too late for inclusion in this guide. Be sure to read it. | — |
| Nonmem7_technical_guide.pdf | Technical Guide on the Expectation-Maximization Population and Monte Carlo Analysis Methods in the NONMEM 7 Program | NONMEM 7 Technical Guide |
| cvs_guide.pdf | Guide on CVODES (ADVAN14) | — |
| cv_guide.pdf | Guide on CVODE (ADVAN14) | — |
| idas_guide.pdf | Guide on IDAS (ADVAN15) | — |
| ida_guide.pdf | Guide on IDA (ADVAN15) | — |
| Manrad5-v2.pdf | Guide on RADAR5 (ADVAN16, ADVAN17) | — |
| Ddes_f90.pdf | Guide on DDE_SOLVER (ADVAN18) | — |
2.6 help.zip
This zip file contains help files for the console help system. The file helptools.zip contains files that is useful with on-line help files in the MS-DOS platform.
2.7 html.zip
This zip file contains files for the help system that can be navigated using an internet browser such as Windows Internet Explorer.
3 Storage of the Distribution Medium
Once the source code has been read, the CD (if you acquired one) should be stored in a safe place for subsequent use. If you erase the source code from disk after installation, you will have to read it back from the original medium to make corrections or changes. If at some future time you wish to transfer NONMEM to a different computer, you should re-install it from the original medium. If you terminate your NONMEM license, you must destroy all computer files containing NONMEM system source, binary code, and derivative products, and return the medium to the distributor, ICON Plc Development Solutions.