17  Other Files on the Distribution Medium

This chapter discusses the remaining files on the distribution medium.

1 Files for Installation Tests

In Chapters III, IV and V, we recommend that you try simple test cases after installing each component of the NONMEM system. The files necessary for these tests are printed in other Users Guides, and are also provided on the distribution medium. These files are located in the util directory of the installed nonmem directory:

PRED1 - PRED subroutine for Chapter III (NONMEM)

Printed as Figure 1 in NONMEM Users Guide I.

CONTROL1 - Control file for Chapter III (NONMEM)

Printed as Figure 2 in NONMEM Users Guide I.

PK1 - PK subroutine for Chapter IV (PREDPP)

Printed as Figure 7 in NONMEM Users Guide VI.

ERROR1 - ERROR subroutine for Chapter IV (PREDPP)

Printed as Figure 11 in NONMEM Users Guide VI.

CONTROL2 - Control file for Chapter IV (PREDPP)

Printed as Figure 25 in NONMEM Users Guide VI.

CONTROL3 - Control file for Chapter V (NM-TRAN)

Printed in Appendix IX in NONMEM Users Guide IV.

DATA3 - Data file for Chapter V (NM-TRAN)

Printed in Appendix IX in NONMEM Users Guide IV.

Additional installation test files are located in

https://nonmem.iconplc.com/nonmem760/STDRESULTSNONMEM760

2 Phenobarbital and Theophylline Data Files

PHENO - Phenobarbital Data

This is the complete data for the Phenobarbital example used in NONMEM Users Guide V (Introductory), Chapter II and Chapter XI. The record length is 80 bytes. There are 745 lines in the file.

THEO - Theophylline Data for PRED

This is the theophylline data for the first illustrative run of Chapter I, Section 2.5 of this guide, which uses PRED abbreviated code, not PREDPP. The data are printed in Users Guide IV, Appendix II. The record length is 80 bytes. There are 132 lines in the file.

THEOPP - Theophylline Data for PREDPP

This is the theophylline data for the second, third, and fourth illustrative runs of Chapter I, Section 2.5, of this guide, which use PREDPP. The data are printed in NONMEM Users Guide IV, Appendix VI. The record length is 80 bytes. There are 144 lines in the file. Note that the data of THEO are identical to that of THEOPP, except that each subject’s dose amount is recorded separately from his first plasma concentration, as required with PREDPP.

3 NM-TRAN Control Streams for Illustrative Runs

CONTROL4 - Theophylline control file: PRED abbreviated code

This is a double precision version of the the NM-TRAN control stream for the first illustrative run of Chapter I, Section 2.5, of this guide. The contents of the file is printed in Users Guide IV, Chapter I. The data of file “THEO” should be used with this control stream.

CONTROL5 - Theophylline control file: PREDPP with ADVAN2

This is a double precision version of the NM-TRAN control stream for the second illustrative run of Chapter I, Section 2.5. The contents of the file is printed in Users Guide IV, Chapter V.

The data of file “THEOPP” should be used with this control stream. It produces essentially the same result as the first illustrative run, but uses PREDPP and the One Compartment Model with First Order Absorption (ADVAN2).

CONTROL6 - Theophylline control file: PREDPP with ADVAN7

This is a double precision version of the NM-TRAN control stream for the third illustrative run of Chapter I, Section 2.5. The contents of the file is printed in Users Guide IV, Appendix VIII. The data of file “THEOPP” should be used with this control stream. It produces essentially the same result as the second illustrative run, but uses PREDPP and the General Linear Method with Real Eigenvalues (ADVAN7). Normally, one would not use ADVAN7 when it is possible to use ADVAN2 because of the increased run time, but this is done here to provide an illustration of comparative executable sizes and run times.

CONTROL7 - Theophylline control file: PREDPP with ADVAN6

This is a double precision version of the NM-TRAN control stream for the fourth illustrative run of Chapter I, Section 2.5. The contents of the file is printed in Users Guide IV, Appendix VIII. The data of file “THEOPP” should be used with this control stream. It produces essentially the same result as the second illustrative run, but uses the General Non-Linear Kinetics Method (ADVAN6). Normally, one would not use ADVAN6 when it is possible to use ADVAN2 because of the increased run time, but this is done here to provide an illustration of comparative executable sizes and run times.

4 Example Control Stream Files

Additional control stream files are located in the examples directory. Accompanying them are standard NONMEM result files, with which you may compare with your run. These examples are described in Introduction to NONMEM 7.6 guide.